Founded by The Guidone Family after the loss of our daughter/sister, Catherine Elizabeth Guidone, in March 2009, to Trisomy 18, the Littlest Angel Foundation seeks to share our experinece in an effort to raise awareness and support others who are faced with this difficult situation.
Trisomy 18, also known as Edwards syndrome, is a condition which is caused by a error in cell division, known as meiotic disjunction. Trisomy 18 occurs in about 1 out of every 2500 pregnancies in the United States, about 1 in 6000 live births. The numbers of total births increase significantly when stillbirths are factored in that occur in the 2nd and 3rd trimesters of pregnancy. Unlike Down syndrome, which also is caused by a chromosomal defect, the developmental issues caused by Trisomy 18 are associated with medical complications that are more potentially life-threatening and 50% of babies who are carried to term will be stillborn.